Exploration for blood biomarkers of human long non-coding RNAs predicting oxaliplatin-induced chronic neuropathy through iPS cell-derived sensory neuron analysis

We explored extracellular long non-coding RNAs (lncRNAs) released from primary sensory neurons as biomarker candidates for oxaliplatin-induced peripheral neuropathy. Because many human-specific lncRNA genes exist, we induced peripheral sensory neurons from human induced pluripotent stem cells. Oxaliplatin treatment changed the levels of many lncRNAs in extracellular vesicles (EVs) released from cultured primary sensory neurons. EV and cellular total RNA obtained from oxaliplatin-treated primary sensory neurons induced from human iPS cells