Identification of monogenic obesity variants in patients with early-onset obesity.

Early-onset obesity is a rising health concern influenced by heredity. However, many monogenic obesity variants (MOVs) remain to be discovered due to differences in ethnicity and culture. Additionally, Patients with known MOVs have shown limited weight loss after bariatric surgery, suggesting it can be used as a screening tool for new variants. In this study, we performed whole-exome sequencing (WES) combined with weight data after bariatric surgery to detect MOVs in a cohort of 62 early-onset obesity and 9 later-onset obesity patients.