Structure of human DNMT2 with bound allosteric inhibitor

Structure of human DNMT2 with bound allosteric inhibitor Descriptor: 4-ethyl-~{N}-[[1-[[(2~{R})-1-(1~{H}-indol-3-yl)-4-[[2-(methylamino)-2-oxidanylidene-ethyl]amino]-4-oxidanylidene-butan-2-yl]carbamoyl]cyclopropyl]methyl]benzamide, GLYCEROL, tRNA (cytosine(38)-C(5))-methyltransferase Authors: Schwan, M, Kopp, J, Sinning, I. Deposit date: 2024-11-20 Release date: 2025-08-27 Last modified: 2025-09-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site. Iscience, 28, 2025