Modular microenvironment components reproduce vascular dynamics de novo in a multi-scale agent-based model: SITE ARCHITECTURE

Data and results for `SITE ARCHITECTURE` simulations.

Simulations of cancerous cells in colony and tissue contexts with different source (points and grids), pattern, and graph site layouts. Each condition is run for 15 days (21600 ticks) with 10 replicates (random seeds 0 - 9). Cancerous cells (max_height x 1.5, meta_pref x 1.5, migra_threshold x 0.5) are introduced to the center of the environment after a 1 day delay. Snapshots are taken every 0.5 days (720 ticks). The data folder contains .tar.xz compressed replicate sets. The results folder contains .pkl files of data parsed into arrays. Simulations are labeled as: [context]_[sites]_[configuration]

- [context]
- C = colony context, cancerous cells only
- CH = tissue context, cancerous cells and healthy cells
- [sites]
- SOURCE = sites architecture defined by point (or set of points) sources
- PATTERN = site architecture defined by pattern
- GRAPH = site architecture defined by graph layout
- [configuration]
- SOURCE
- constant = every point is a source, equivalent to constant source
- point# = point source located at position # from center
- grid# = grid of point sources with # spacing in both the x and y directions
- xAyB = grid of point sources with A spacing in the x direction and B spacing in the y direction
- nosite = no point is a source
- PATTERN
- simulations with PATTERN do not have a configuration label
- GRAPH
- Lav = line root graph with one artery and one vein (L11)
- Lava = line root graph with two arteries and one vein (L21)
- Lvav = line root graph with one artery and two veins (L12)
- Sav = single root graph with one artery and one vein (S11)
- Savav = single root graph with two arteries and two veins (S22)

本数据集包含了关于`场地架构`模拟的数据与结果。
在群落和组织背景下，针对不同来源（点与网格）、模式及图形场地布局进行癌细胞模拟。每个条件均进行为期15天（21600个时间单位）的模拟，共进行10次重复（随机种子0至9）。在延迟1天后，将癌细胞（最大高度为x 1.5，元偏好值为x 1.5，迁移阈值x 0.5）引入环境的中心。每0.5天（720个时间单位）进行一次快照。数据文件夹包含压缩的重复集（.tar.xz格式）。结果文件夹包含解析为数组的文件（.pkl格式）。模拟以以下格式标注：[背景]_[场地]_[配置]

- [背景]
- C = 群落背景，仅包含癌细胞
- CH = 组织背景，包含癌细胞和健康细胞
- [场地]
- SOURCE = 由点（或点集）源定义的场地架构
- PATTERN = 由模式定义的场地架构
- GRAPH = 由图形布局定义的场地架构
- [配置]
- SOURCE
- constant = 每个点都是源，等同于恒定源
- point# = 位于中心位置#的点源
- grid# = x和y方向间距为#的点源网格
- xAyB = x方向间距为A，y方向间距为B的点源网格
- nosite = 没有点是源
- PATTERN
- 使用PATTERN的模拟没有配置标签
- GRAPH
- Lav = 具有一条动脉和一条静脉的线根图（L11）
- Lava = 具有两条动脉和一条静脉的线根图（L21）
- Lvav = 具有一条动脉和两条静脉的线根图（L12）
- Sav = 具有一条动脉和一条静脉的单根图（S11）
- Savav = 具有两条动脉和两条静脉的单根图（S22）