TOP3A
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1319604
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资源简介：
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
该基因编码一种DNA拓扑异构酶，一种调控并改变DNA转录过程中拓扑状态的酶。此酶催化DNA单链的暂时性断裂与重新连接，使得单链得以相互穿越，从而减少超螺旋的数量并改变DNA的拓扑结构。该酶与BLM蛋白形成复合物，BLM蛋白在体细胞重组调控中发挥作用。可变剪接导致多种转录变体产生，这些变体编码不同的异构体。[由RefSeq提供，2016年3月]
提供机构：
Rat Genome Database
