遇见数据集

Canonical PRC1 recruitment is promoted by EZH1-1 PRC2 independent of H3K27me3 in quiescent cells

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Mendeley Data2026-04-18 收录
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Raw Western blots of paper, entitled "Canonical PRC1 recruitment is promoted by EZH1-1 PRC2 independent of H3K27me3 in quiescent cells". A Non-Catalytic Role of EZH1-PRC2 to Promote Canonical PRC1 Recruitment in Quiescent Cells Evan Healy1,2*, Rachel McCole1*, James Nolan1,3, Craig Monger1, Eric Conway1,4, Gerard L. Brien1, Cheng Wang1, Orla Deevy1, Hannah K. Neikes5, Frances Potjewyd6, Aoibhinn Mooney7,8, Richard Flavin7,8, Elisabeth Vandenberghe3, Sarena F. Flanigan2, Chen Davidovich2,9, Michiel Vermeulen5, Lindsey I. James6,10, Adrian P. Bracken1†. 1Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland. 2Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia. 3Department of Haematology, St. James’ Hospital, Dublin 8, Ireland. 4School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland. 5Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands. 6Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. 7Department of Histopathology, St. James’ Hospital, Dublin 8, Ireland. 8Department of Histopathology, Trinity College Dublin, Dublin 2, Ireland. 9EMBL-Australia, Clayton, VIC, Australia. 10Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. *These authors contributed equally. †Corresponding author: Dr. Adrian P. Bracken (adrian.bracken@tcd.ie).

本数据集为标题为《静息细胞中不依赖组蛋白H3赖氨酸27三甲基化(H3K27me3)的EZH1-PRC2促进经典PRC1募集》的论文的原始蛋白质免疫印迹(Western Blot)数据。 论文正式标题:《静息细胞中EZH1-PRC2通过非催化功能促进经典PRC1募集》 作者:Evan Healy1,2*、Rachel McCole1*、James Nolan1,3、Craig Monger1、Eric Conway1,4、Gerard L. Brien1、Cheng Wang1、Orla Deevy1、Hannah K. Neikes5、Frances Potjewyd6、Aoibhinn Mooney7,8、Richard Flavin7,8、Elisabeth Vandenberghe3、Sarena F. Flanigan2、Chen Davidovich2,9、Michiel Vermeulen5、Lindsey I. James6,10、Adrian P. Bracken1† 1 斯默菲特遗传学研究所,都柏林圣三一学院,爱尔兰都柏林2区 2 生物化学与分子生物学系、生物医学发现研究所、医学、护理与健康科学学院,莫纳什大学,澳大利亚维多利亚州克莱顿 3 血液科,圣詹姆斯医院,爱尔兰都柏林8区 4 生物分子与生物医学科学学院,都柏林大学学院,爱尔兰都柏林4区 5 分子生物学系、理学院、拉德堡德分子生命科学研究所、Oncode研究所,奈梅亨拉德堡德大学,荷兰奈梅亨6525 GA 6 整合化学生物学与药物发现中心、化学生物学与药物化学分部,北卡罗来纳大学教堂山分校埃什尔曼药学院,美国北卡罗来纳州教堂山市27599 7 病理科,圣詹姆斯医院,爱尔兰都柏林8区 8 病理科,都柏林圣三一学院,爱尔兰都柏林2区 9 欧洲分子生物学实验室澳大利亚分部(EMBL-Australia),澳大利亚维多利亚州克莱顿 10 林伯格综合癌症中心、医学院,北卡罗来纳大学教堂山分校,美国北卡罗来纳州教堂山市27599 * 共同第一作者 † 通讯作者:Adrian P. Bracken博士(邮箱:adrian.bracken@tcd.ie)

创建时间:
2023-01-27
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