Top 52 cell surface sialoglycoproteins overexpressed in GBM tumor cells.

aProteomic analysis of differential sialoglycoprotein expression in glioblastoma multiform (GBM) cells compared to astrocytes or neural progenitor cells (NPCs). Effect size (Log2 values) indicate the standardized mean difference in protein expression level between primary tumor cells (SIDs) and astrocytes or NPCs. For each protein, the median intensity level (linear scale) in the tumor group is indicated. Normalized protein intensities used to calculate effect sizes are listed in Table S3.
bMicroarray and quantitative real-time PCR (qPCR) analyses of differential gene expression in GBM cells compared to adult astrocytes. For each tumor sample, fold-change expression ratios per gene between SIDs and adult astrocytes (control) were calculated. The median fold-change expression ratio per gene is indicated. Array and qPCR data are detailed in Tables S4 and S6, respectively.
cThe gene expression up- or down-regulation in glioblastoma are obtained from a large scale meta-analysis of glioblastoma public microarray data from independent studies downloaded from the Gene Expression Atlas database (http://www.hprd.org/). The number of studies the gene is over- or -under expressed in glioblastoma tissues or cell lines is indicated in parentheses. Data are detailed in Table S5.
dProtein expression profiles in malignant glioma based on immunohistochemistry for a large number of human tissues, cancers and cell lines are obtained from The Human Protein Atlas portal (http://www.proteinatlas.org/). For each indicated protein, overall malignant glioma tissue staining statistics (percentage of tumors positive for the protein studied) are reported in Table S7.
ND: not determined.
Top 52 cell surface sialoglycoproteins overexpressed in GBM tumor cells.