The CARDIA-GENEVA Study

For the GENEVA CARDIA project, three genotype call sets were generated from a single set of array scans as a consequence of DNA sample quality problems. These call sets are designated "Birdsuite-1", "Birdsuite-2" and "Beaglecall". ("Beaglecall" used both Birdseed and BEAGLECALL calling algorithms.) An analysis-ready genotypic data set is provided in PLINK format for the "Beaglecall" set only, because it performs very well in QC analyses. Only raw CHP and ALLELE_SUMMARY files are provided for the two Birdsuite call sets because they have significant quality issues. Use of the Beaglecall set is highly recommended. Users of the other two call sets should proceed with caution. More details are given in the genotypic QC report. The CARDIA study, sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective, multi-center investigation of the natural history and etiology of cardiovascular disease in African-Americans and Whites 18-30 years of age at the time of initial examination. The initial examination included 5,115 participants selectively recruited to represent proportionate racial, gender, age, and education groups from 4 communities: Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. Participants from the Birmingham, Chicago, and Minneapolis centers were recruited from the total community or from selected census tracts. Participants from the Oakland center were randomly recruited from the Kaiser-Permanente health plan membership. From the time of initiation of the study in 1985-1986, five follow-up examinations have been conducted at years 2, 5, 7, 10, 15, and 20. The Year 25 examination is scheduled to begin in 2010. This study is part of the Gene Environment Association Studies initiative (GENEVA, http://www.genevastudy.org) funded by the trans-NIH Genes, Environment, and Health Initiative (GEI). The overarching goal is to identify novel genetic factors associated with variation in longitudinal blood pressure profiles during the critical transition period from young adulthood to early middle-age; and to characterize their interactions with relevant environmental factors, such as body weight profiles. Genotyping was performed at the Broad Institute of MIT and Harvard, a GENEVA genotyping center. Data cleaning and harmonization were performed at the GEI-funded GENEVA Coordinating Center at the University of Washington.]]>
Telephone Interview Parts I & IITobacco QuestionnaireBlood PressureAnthropometrySociodemographicsCardia Phlebotomy FormFollowup Questions for Heart ProblemsCARDIA II Tobacco QuestionnaireCARDIA II Blood PressureCARDIA II AnthropometryCARDIA II PhlebotomyCARDIA II Follow-up Questions for Heart ProblemsCARDIA II Follow-up Questions for Antihypertentive MedicationsCARDIA III Tobacco QuestionnaireCARDIA III Blood PressureCARDIA III Anthropometry Version 2CARDIA III PhlebotomyCARDIA III Medical HistoryCARDIA Year 20 Exam Consent FormCARDIA Year 20 Exam Consent FormCARDIA Year 20 Exam Consent FormKAISER FOUNDATION HOSPITALS CONSENT TO PARTICIPATE IN A MEDICAL RESEARCH STUDYManuscripts, published or accepted, 1987 - 2010, CARDIA StudyForm 09/Form 10 - NOTES AND COMPUTED VARIABLES (Tobacco Questionnaire)CARDIA IV Tobacco QuestionnaireCARDIA IV Blood PressureCARDIA IV Anthropometry Version 2CARDIA IV PhlebotomyCARDIA IV Medical HistoryCARDIA V Tobacco QuestionnaireCARDIA V Blood PressureCARDIA V AnthropometryCARDIA V Phlebotomy Version 5CARDIA V Medical HistoryCARDIA VI Tobacco QuestionnaireCARDIA VI Blood PressureCARDIA VI AnthropometryCARDIA VI PhlebotomyCARDIA VI Medical HistoryY20 - CARDIA VII Tobacco QuestionnaireY20 - CARDIA VII Blood PressureY20 - CARDIA VII AnthropometryY20 - CARDIA VII PhlebotomyY20 - CARDIA VII Medical HistoryManual of Operations, 6/85Exam 1 Blood Drawing/Handling Manual (PHL)Exam 1 Phlebotomy Protocol (PHL)Exam 2 Blood Drawing/Handling Manual (PHL)Exam 2 Phlebotomy Protocol (PHL)Exam 3 Blood Drawing/Handling Manual (PHL)Exam 3 Phlebotomy Protocol (PHL)Exam 4 Blood Drawing/Handling Manual (PHL)Exam 4 Phlebotomy Protocol (PHL)Exam 5 Blood Drawing/Handling Manual (PHL)Exam 5 Chemistries ProtocolExam 6 Blood Drawing/Handling Manual (PHL)Exam 6 Phlebotomy Protocol (PHL)Exam 7 Blood Drawing/Handling Manual (PHL)CARDIA Y20 Exam VII ProtocolAfrican-Americans and Whites aged 18-30 at the baseline examination]]>
The cohort has been examined at 7 clinic visits, with an 8th visit scheduled. Baseline Examination: 1985-1986 Exam 2: 1987-1988 Exam 3: 1990-1991 Exam 4: 1992-1993 Exam 5: 1995-1996 Exam 6: 2000-2001 Exam 7: 2005-2006 Exam 8: (ongoing) 2010-2011 ]]>