Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.

Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor. Descriptor: 3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE, Hepatitis C virus NS5B RNA polymerase Authors: Love, R.A, Parge, H.E, Yu, X, Hickey, M.J, Diehl, W, Gao, J, Wriggers, H, Ekker, A, Wang, L, Thomson, J.A, Dragovich, P.S, Fuhrman, S.A. Deposit date: 2003-03-18 Release date: 2004-03-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J.Virol., 77, 2003

丙型肝炎病毒（Hepatitis C virus, HCV）NS5B RNA聚合酶与新型非竞争性抑制剂结合的晶体结构。描述物：3-(4-氨基-2-叔丁基-5-甲基苯基硫基)-6-环戊基-4-羟基-6-[2-(4-羟基苯基)乙基]-5,6-二氢吡喃-2-酮。作者：Love, R.A、Parge, H.E、Yu, X、Hickey, M.J、Diehl, W、Gao, J、Wriggers, H、Ekker, A、Wang, L、Thomson, J.A、Dragovich, P.S、Fuhrman, S.A。沉积日期：2003-03-18；发布日期：2004-03-18；最后修改日期：2024-04-03。研究方法：X射线衍射（分辨率2.2 Å）。引用文献：《丙型肝炎病毒NS5B RNA聚合酶上非竞争性抑制剂结合位点的晶体学鉴定》，《病毒学杂志》，77卷，2003年。