Immunohistochemical Scoring of Notch Signaling Components in the whole cohort of pediatric patients with rhabdomyosarcomas (RMS) and in alveolar (PAX3-FOXO1, n = 10; PAX7-FOXO1, n = 2) and embryonal (n = 20) RMS subtypes.

Data are expressed as median values semi-quantified as the percentage of positive nuclei per microscopic field (range in parentheses). Alveolar tumors were confirmed as PAX-FOXO1 fusion positive and Embryonal tumors as PAX-FOXO1 fusion-negative).*P: Mann-Whitney test for ARMS vs ERMS values;†P and ‡P: Fisher's exact test for Notch3 vs Notch1 and HES1 vs HEY1 values within each RMS subtype, respectively.