Circulating CircRNA expression profiling of Graves' disease

NGS was performed to detect human circRNAs. We found many upregulated and downregulated circRNAs in GD patients. Through high-throughput sequencing technology, 23215 upregulated and 13715 down-regulated circRNAs were detected between gd patient group and the healthy control group. Of the 218 circRNAs with significant difference, 359 were up-regulated and 309 were down-regulated. Overall design: Circulating circRNA profiles of five Graves' disease patients and five healthy volunteers were generated by deep sequencing,using Illumina HiSeq 4000