The effects of phenformin, resveratrol, AICAR or cycloheximide on nucleolar proteins are summarized.

Results are depicted for individual compartments (nucleus, cytoplasm, nucleolus) or the distribution nucleus/cytoplasm (Nuc/Cyt), nucleolus/nucleus (No/Nuc) and nucleolus/cytoplasm (No/Cyt). The drug-induced reduction in de novo RNA synthesis is shown for comparison [14]. Results for control samples were defined as 1, and arrows denote the changes relative to controls: 0–0.24, ↓↓; 0.25–0.74, ↓; 0.75–1.24, ↔; 1.25–1.74, ↑; 1.75–2.24, ↑↑.