Ternary complex of DNA Polymerase Beta with Template Fapy-dG and an incoming dCTP analog

Ternary complex of DNA Polymerase Beta with Template Fapy-dG and an incoming dCTP analog Descriptor: 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(FAP)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... Authors: Freudenthal, B.D, Ryan, B.J, Smith, M.R. Deposit date: 2021-09-21 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication. J.Am.Chem.Soc., 144, 2022

携带模板甲酰胺嘧啶脱氧鸟苷（Fapy-dG）与待掺入的脱氧胞苷三磷酸（dCTP）类似物的DNA聚合酶β（DNA Polymerase β）三元复合物
描述：2'-脱氧-5'-O-[(S)-羟基{[(S)-羟基(膦酰氧基)膦酰基]甲基}膦酰基]胞苷、氯离子、DNA（5'-D(*CP*CP*GP*AP*CP*(FAP)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'）……
作者：Freudenthal, B.D、Ryan, B.J、Smith, M.R.
存档日期：2021-09-21
发布日期：2022-08-03
末次修改日期：2023-10-18
实验方法：X射线衍射法（分辨率1.86埃）
引用文献：《双链DNA中及DNA复制过程中常见致突变氧化DNA损伤的结构动力学》（Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication），《美国化学会志》（J. Am. Chem. Soc.），第144卷，2022年