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Small molecules that induce proliferation of human iPSC-cardiomyocytes

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NIAID Data Ecosystem2026-05-02 收录
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We selected a set of five compounds with diverse known targets that induce proliferation of human iPSC-derived cardiomyocytes. We performed bulk RNA-sequencing of human iPSC-CMs in response to the five compounds to identify common mechanisms mediating compound-induced cell cycle progression. Transcriptome profiling revealed these compounds all induced a common set of pathways including cell cycle, DNA repair, and kinesins.

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2024-05-15
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