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资源简介：
The study of the role/influence of A. thaliana SR proteins (RS31 and RS2Z33) on alternative splicing
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创建时间：
2017-03-15
相关数据集
Effect of SRSF2 over-expression in a human lung carcinoma cell line
We showed that the over-expression of the SR protein SRSF2 led to the regulation of transcript abundance of many genes. H358 cell line with 6 samples with SRSF2 over-expression and 6 samples as contro
NIAID Data Ecosystem40
SR Proteins Collaborate with 7SK and Promoter-Associated Nascent RNA to Release Paused Polymerase. Mus musculus
RNAP II is frequently paused near gene promoters in mammals and its transition to productive elongation requires active recruitment of P-TEFb, a cyclin-dependent kinase for RNAP II and other key trans
NIAID Data Ecosystem40
A unified activation mechanism for mRNA 3’ end processing and splicing mediated by SR superfamily proteins. Homo sapiens
Alternative mRNA processing is a critical mechanism for proteome expansion and gene regulation in higher eukaryotes. The SR family proteins play important roles in splicing regulation. Intriguingly, m
NIAID Data Ecosystem20
Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay
One important task of eukaryotic cells is to translate only mRNAs that were correctly processed to prevent the production of truncated proteins, found in neurodegenerative diseases and cancer. Nuclear
NIAID Data Ecosystem40
Knockdown of SR protein family in P19 cells and RNA-seq of cytoplasmic and whole cell polyA+ RNA
Our data suggest that all SR proteins contribute to mRNA export via NXF1. To identify endogenous export targets we depleted all seven SR proteins individually from P19 WT cells prepared cytoplasmic fr
NIAID Data Ecosystem20
