Correction: Small-Molecule Inhibitors of Dengue-Virus Entry

NIAID Data Ecosystem2026-03-10 收录

登革病毒药物发现

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https://figshare.com/articles/dataset/Correction_Small-Molecule_Inhibitors_of_Dengue-Virus_Entry/7657925 数据链接链接失效反馈

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资源简介：

Correction: Small-Molecule Inhibitors of Dengue-Virus Entry

创建时间：

2019-01-31

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors

登革病毒药物发现

抑制剂优化

In the absence of any approved dengue-specific treatment, the discovery and development of a novel small-molecule antiviral for the prevention or treatment of dengue are critical. We previously report

NIAID Data Ecosystem80

Unbinding pathways and energetics of papaya-derived flavonoids as dengue MTase inhibitors via SMD-US and MMGBSA methods

登革病毒药物发现

计算药物化学

Dengue virus methyltransferase (DENV MTase) facilitates the methylation of the viral RNA cap and continues to be a confirmed target for antiviral development. This study examined papaya-derived flavon

Figshare2025-11-14 更新40

Antiviral activity and cytotoxicity of K5 derivatives in HMEC-1 cells.

登革病毒药物发现

细胞毒性评估

CC50: cytotoxic concentration or drug concentration required to reduce cell viability by 50% as measured by MTS assay. EC50: effective concentration or drug concentration required to inhibit DENV-2 in

NIAID Data Ecosystem30

Top in vitro hits from NCI diversity set compounds towards both S1 and S2 pockets of DENV-2 NS2B/NS3pro.

登革病毒药物发现

抑制剂筛选

Top in vitro hits from NCI diversity set compounds towards both S1 and S2 pockets of DENV-2 NS2B/NS3pro.

Figshare2019-01-24 更新40

Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z383325512 (DNV2_NS5A-x0829)

登革病毒药物发现

RNA聚合酶结构生物学

NIAID Data Ecosystem30