DNA Methylation Potential Energy Landscape Analysis of MLL-rearranged Acute Myeloid Leukemia (AML) and Normal hematopoietic precursors [WGBS]

Acute myeloid leukemia (AML) carrying MLL rearrangements. We applied WGBS and the informME analysis pipeline to investigate the role of DNA methylation stochasticity in MLL-rearranged AML. Overall design: WGBS was carried out on primary acute myeloid leukemia samples harboring KMT2A (MLL) rearrangements and on normal human myeloid progenitor cells.