Therapeutic IDOL reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice
收藏NIAID Data Ecosystem2026-05-02 收录
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An antisense oligonucleotide (ASO) against E3 ubiquitin ligase IDOL in the brain significantly decreased Aβ pathology, and improved spatial learning and memory in APP/PS1 mice. Drop-Seq was performed on 6 B6.Cg-Tg( APPswe,PSEN1dE9) 85Dbo/Mmjax (005864) mice. 3 mice were treated with ASO, and 3 treated with PBS.
创建时间：
2024-10-22
