Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide
收藏Protein Data Bank Japan2023-09-13 更新2026-03-21 收录
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Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide Descriptor: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide, RNA-directed RNA polymerase, ... Authors: Sheriff, S. Deposit date: 2011-01-24 Release date: 2011-04-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.22 Å) Cite: Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase. Bioorg.Med.Chem.Lett., 21, 2011
丙型肝炎病毒（Hepatitis C Virus, HCV）NS5B RNA依赖的RNA聚合酶（RNA-dependent RNA polymerase）复合物与(2E)-3-(4-{[(1-{[(13-环己基-6-氧代-6,7-二氢-5H-吲哚并[1,2-d][1,4]苯并二氮杂䓬-10-基)羰基]氨基}环戊基)羰基]氨基}苯基)丙-2-烯酸以及N-环丙基-6-[(3R)-3-{[4-(三氟甲氧基)苄基]氨基甲酰基}-4-{[4-(三氟甲氧基)苯基]磺酰基}哌嗪-1-基]哒嗪-3-甲酰胺的晶体结构
描述符：(2E)-3-(4-{[(1-{[(13-环己基-6-氧代-6,7-二氢-5H-吲哚并[1,2-d][1,4]苯并二氮杂䓬-10-基)羰基]氨基}环戊基)羰基]氨基}苯基)丙-2-烯酸、N-环丙基-6-[(3R)-3-{[4-(三氟甲氧基)苄基]氨基甲酰基}-4-{[4-(三氟甲氧基)苯基]磺酰基}哌嗪-1-基]哒嗪-3-甲酰胺、RNA定向RNA聚合酶（RNA-directed RNA polymerase）……
作者：Sheriff, S.
存放日期：2011-01-24
发布日期：2011-04-20
最后修改日期：2023-09-13
实验方法：X射线衍射（3.22 Å）
引用文献：探究新型N-苄基-4-杂芳基-1-(苯磺酰基)哌嗪-2-甲酰胺类化合物与丙型肝炎病毒聚合酶的结合模式。Bioorg.Med.Chem.Lett., 21, 2011
创建时间：
2011-01-24
