Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.

Name: Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.
Creator: National Academy of Sciences
Published: 1991-05-01 00:00:00
License: 暂无描述

PubMed Central1991-05-01 更新2026-05-16 收录

下载链接：

https://pmc.ncbi.nlm.nih.gov/articles/PMC51527/

下载链接

链接失效反馈

官方服务：

资源简介：

CENP-A, a centromere-specific 17-kDa protein, has histone-like properties. However, in contrast to the common somatic histones, CENP-A is quantitatively retained in bull spermatozoa, and we have exploited this fact to purify CENP-A to apparent homogeneity. Partial sequence analysis of the purified protein indicates that CENP-A is a distinctive gene product. Some CENP-A sequences are highly similar to regions of histone H3. Other segments of CENP-A are not related to H3 or any other histone. These unrelated segments are presumably involved in localizing CENP-A to centromeric DNA or in centromere-specific functions of CENP-A. IMAGES:

提供机构：

National Academy of Sciences

创建时间：

1991-05-01