Effect van verwarmde oxaliplatin op acute perifere neuropathie klachten bij patienten die aanvullend of voor een gevorderde of uitgezaaide darmkanker behandeld worden met oxaliplatin houdende chemotherapie.

Interventions: Oxaliplatin will be heated to a temperature of 36 degrees celsius during the 2-hours infusion period, irrespective the standard prophylaxis with magnesium and calcium.
Primary outcome(s): 1. Decrease of the acute peripheral neuropathy complaints with 1 point or more on the four points scale of the Total Neuropathy Score;
2. Changes in quality of life (cancer related and symptom related) in the period after infusion of heated oxaliplatin in comparison with the period after infusion of oxaliplatin on roomtemperature.
Study Design: N/A: single arm study, Open (masking not used), N/A , unknown, Parallel