Catalytic Asymmetric Access to Noncanonical Chiral α‑Amino Acids from Cyclic Iminoglyoxylates and Enamides

Here
we describe an enantioselective Mannich reaction of cyclic
iminoglyoxylates with enamides by virtue of chiral phosphoric acid
catalysis in a one-pot manner. The wide substrate scope, mild reaction
conditions, and constantly excellent enantioselectivities (>95%
ee
in most cases) render this protocol highly practical for the rapid
construction of valuable noncanonical chiral α-amino-acid building
blocks.