Metabolic changes after one week treatment with sertraline and placebo.

Changes in absolute concentrations of metabolites (log-transformed) after one week are shown; positive values – up-regulated metabolites, negative values– down-regulated metabolites. Significant changes are shown in bold. See methods section for the details of statistical analysis. Abbreviations: 5-MTPM – 5-methoxytryptamine; for the remaining metabolites, see Table 1.