Activation recovery interval imaging of premature ventricular contraction

Dispersion of ventricular repolarization due to abnormal activation contributes to the susceptibility to cardiac arrhythmias. However, the global pattern of repolarization is difficult to assess clinically. Activation recovery interval (ARI) has been used to understand the properties of ventricular repolarization. In this study, we developed an ARI imaging technique to noninvasively reconstruct three-dimensional (3D) ARI maps in 10 premature ventricular contraction (PVC) patients and evaluated the results with the endocardial ARI maps recorded by a clinical navigation system (CARTO). From the analysis results of a total of 100 PVC beats in 10 patients, the average correlation coefficient is 0.86±0.05 and the average relative error is 0.06±0.03. The average localization error is 4.5±2.3 mm between the longest ARI sites in 3D ARI maps and those in CARTO endocardial ARI maps. The present results suggest that ARI imaging could serve as an alternative of evaluating global pattern of ventricu...异常激活所致的心室复极离散度是心律失常易感性的重要诱因。然而，临床中难以对复极的整体模式进行评估。激动恢复间期（Activation Recovery Interval, ARI）常被用于探究心室复极的特性。本研究开发了一种ARI成像技术，可对10例室性早搏（Premature Ventricular Contraction, PVC）患者的三维（3D）ARI标测图进行无创重建，并通过临床导航系统（CARTO）记录的心内膜ARI标测图对重建结果进行验证。对10例患者共100次PVC心搏的分析结果显示，相关系数均值为0.86±0.05，相对误差均值为0.06±0.03；三维ARI标测图与CARTO心内膜ARI标测图中最长ARI位点的平均定位误差为4.5±2.3 mm。本研究结果表明，ARI成像可作为评估心室整体复极模式的替代手段...