We analyzed levels of 5-methyl cytosine CCCGGG target sites by sequential restriction digest by SmaI and XmaI enzymes, ligating Illumina adaptors to the restriction fragments and reading methylation-s
aType I S genes were classified according to orthologous groups [18].bClassification based on amino acid sequence similarity[18].cAdenine detected as methylated is underlined.dY, C or T; R, A or G; V,
