Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076

Protein Data Bank Japan2023-10-18 更新2026-04-19 收录

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Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]benzoyl}-L-glutamic acid Authors: Chan, A, Schonbrunn, E. Deposit date: 2021-05-07 Release date: 2022-05-11 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076 To Be Published

人源BRD4首个溴结构域（bromodomain, BD1）与GXH-II-076结合的晶体结构描述：1,2-乙二醇、含溴结构域蛋白4（Bromodomain-containing protein 4）、N-{3-[(2-{3-氟-4-[(哌啶-4-基)氨基甲酰基]苯胺基}-5-甲基嘧啶-4-基)氨基]-5-[(2-甲基丙烷-2-磺酰基)氨基]苯甲酰基}-L-谷氨酸作者：Chan A、Schonbrunn E 沉积日期：2021-05-07 发布日期：2022-05-11 最后修改日期：2023-10-18 实验方法：X射线衍射（分辨率1.2埃）引用信息：人源BRD4首个溴结构域（BD1）与GXH-II-076结合的晶体结构 [待发表]

创建时间：

2021-05-07