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ATAC-seq of germinal center B cell-derived cell lines after POU2F2 or POU2AF1 knockdown

NIAID Data Ecosystem2026-05-01 收录

染色质可及性分析

转录因子功能研究

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP336384 数据链接链接失效反馈

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资源简介：

ATAC-seq in OCI-Ly7 and SUDHL4 cell lines after CRISPRi knockdown of OCT2 (POU2F2) or OCA-B (POU2AF1), or control non-targeting sgRNAs. Overall design: Comparison of knockdown relative to control.

应用场景：

创建时间：

2023-10-14

细胞分化调控

转录因子功能研究

Transgene insertion in proximity to the c-Myb gene disrupts c-Myb expression in megakaryocyte-erythrocyte progenitors (MEPs), resulting in skewed commitment to megakaryocyte lineage. To understand the

NIAID Data Ecosystem50

Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]. Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]

Th17细胞调控

染色质可及性分析

CD4+ T helper 17 (Th17) cells encompass a spectrum of cell states including homeostatic cells that maintain physiological functions such as barrier integrity and pathogenic cells that drive autoimmune

NIAID Data Ecosystem00

HDMA ChromBPNet contribution scores - Part 2

染色质可及性分析

表观基因组学

Base-resolution contribution scores from ChromBPNet models (in the form of h5 files containing mean scores across folds per cell type), for HDMA (Liu*, Jessa*, Kim*, Ng* et al, bioRxiv 2025). A detail

Zenodo2026-01-07 更新00

ATAC-seq of HEK293 cells with Alu-motif targeted dCas9GFP. ATAC-seq of HEK293 cells with Alu-motif targeted dCas9GFP

染色质可及性分析

基因调控

HEK293 cells were selected and subcloned for doxycyclin (DOX) and trimethoprim (TMP) inducible dCas9GFP and a guide RNA molecule targeting an EGA enriched Alu-motif (EEA-g1). Cells were treated with D

NIAID Data Ecosystem10

The role of a basic amino acid cluster in target site selection and non-specific binding of bZIP peptides to DNA.

蛋白质-DNA互作

转录因子功能研究

The ability of a transcription factor to locate and bind its cognate DNA site in the presence of closely related sites and a vast array of non-specific DNA is crucial for cell survival. The CREB/ATF f

PubMed Central1997-08-01 更新00

ATAC-seq of germinal center B cell-derived cell lines after POU2F2 or POU2AF1 knockdown

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