Chaotropic Effect-Induced Sol–Gel Transition and Radical Stabilization for Bacterially Sensitive Near-Infrared Photothermal Therapy

Deep-seated bacterial infections (DBIs) are stubborn
and deeply
penetrate tissues. Eliminating deep-seated bacteria and promoting
tissue regeneration remain great challenges. Here, a novel radical-containing
hydrogel (SFT-B Gel) cross-linked by a chaotropic effect was designed
for the sensing of DBIs and near-infrared photothermal therapy (NIR-II
PTT). A silk fibroin solution stained with 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)tris(1-methylpyridin-1-ium)
(TPT3+) was employed as the backbone, which could be cross-linked
by a closo-dodecaborate cluster (B12H122–) through a chaotropic effect to form
the SFT-B Gel. More interestingly, the SFT-B Gel exhibited the ability
to sense DBIs, which could generate a TPT2+• radical
with obvious color changes in the presence of bacteria. The radical-containing
SFT-B Gel (SFT-B★ Gel) possessed strong NIR-II absorption and
a remarkable photothermal effect, thus demonstrating excellent NIR-II
PTT antibacterial activity for the treatment of DBIs. This work provides
a new approach for the construction of intelligent hydrogels with
unique properties using a chaotropic effect.