Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-[2-(diethylamino)ethoxy]-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one

Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-[2-(diethylamino)ethoxy]-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one Descriptor: 6-[2-(diethylamino)ethoxy]-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one, Bromodomain-containing protein 4, FORMIC ACID Authors: Lee, B.I, Park, T.H. Deposit date: 2019-07-04 Release date: 2020-07-08 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26, 2021

BRD4溴结构域1（BD1）与6-[2-(二乙氨基)乙氧基]-16-甲氧基-11-甲基-2-氧杂-11-氮杂四环[8.6.1.0³,⁸.0¹³,¹⁷]十七碳-1(17),3,5,7,9,13,15-七烯-12-酮复合物的晶体结构。标注内容：配体为6-[2-(二乙氨基)乙氧基]-16-甲氧基-11-甲基-2-氧杂-11-氮杂四环[8.6.1.0³,⁸.0¹³,¹⁷]十七碳-1(17),3,5,7,9,13,15-七烯-12-酮，靶蛋白为含溴结构域蛋白4（Bromodomain-containing protein 4），结晶溶剂为甲酸（FORMIC ACID）。作者：Lee, B.I.、Park, T.H.。提交日期：2019-07-04，发布日期：2020-07-08，最后修改日期：2023-11-22。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.85 Å。引用文献：《Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research》，发表于《Molecules》，2021年，第26卷。