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Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms

ChEBI2021-04-14 更新2026-07-12 收录

RNA剪接调控

髓系肿瘤病理机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-9709 数据链接链接失效反馈

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Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms

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创建时间：

2021-04-14

剪接保真度

RNA剪接调控

Fidelity of 3´-splice site (3´SS) selection by the spliceosome is critical for proper gene expression but is a daunting task considering the low complexity of the 3´SS consensus YAG. Here we show that

Alliance of Genome Resources40

Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (RNA-Seq II)

RNA剪接调控

表皮细胞分化

Glucose is an important cellular energy source, however, glucose's function as a second messenger remains relatively unexplored. Here, we find that glucose binds directly to DDX21 to regulate its func

NIAID Data Ecosystem30

Structure and Novel Functional Mechanism of Drosophila SNF in Sex-Lethal Splicing

RNA剪接调控

果蝇性别决定

Sans-fille (SNF) is the Drosophila homologue of mammalian general splicing factors U1A and U2B″, and it is essential in Drosophila sex determination. We found that, besides its ability to bind U1 snRN

NIAID Data Ecosystem30

ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing

RNA剪接调控

神经元mRNA处理

ELAV/Hu factors are conserved RNA binding proteins that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago

NIAID Data Ecosystem40

The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation

RNA剪接调控

翻译控制

Recent work has associated point mutations in both zinc fingers (ZnF) of the spliceosome component U2AF35 with malignant transformation. However, surprisingly little is known about the functionality o

NIAID Data Ecosystem30

Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms

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