Proteomic analysis of human eosinophils stimulated with all-trans retinoic acid and IL-5

Activated eosinophils is a major cell type to be involved in allergic diseases. IL-5 primarily activates eosinophils and prolongs their survival. In contrast, all-trans retinoic acid has regulatory effects in the immune system. The aim of this study is to clarify the role of all-trans retinoic acid in the regulation of human eosinophils.