Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1457921102 (A71EV2A-x0911)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1457921102 (A71EV2A-x0911) Descriptor: (3S)-N-methyl-N-phenylpyrrolidine-3-carboxamide, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16（Coxsackievirus A16）G-10株2A蛋白酶晶体学片段筛选数据集提交——与配体Z1457921102（A71EV2A-x0911）结合的柯萨奇病毒A16 G-10株2A蛋白酶晶体结构。描述项：(3S)-N-甲基-N-苯基吡咯烷-3-甲酰胺、二甲基亚砜（DIMETHYL SULFOXIDE）、2A蛋白酶（Protease 2A）等。
作者：Lithgo, R.M.、Fairhead, M.、Koekemoer, L.、Balcomb, B.H.、Capkin, E.、Chandran, A.V.、Golding, M.、Godoy, A.S.、Aschenbrenner, J.C.、Marples, P.G.、Ni, X.、Thompson, W.、Tomlinson, C.W.E.、Wild, C.、Winokan, M.、Xavier, M.-A.E.、Fearon, D.、von Delft, F.
提交日期：2024年4月4日；发布日期：2024年4月24日；最后修改日期：2024年10月16日
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.42埃（Å）
引用文献：《柯萨奇病毒A16 2A蛋白酶晶体学片段筛选发现广谱抗肠病毒研发新方向》，BioRxiv，2024年