MOESM2 of Epigenome-wide association study of asthma and wheeze characterizes loci within HK1

Additional file 2: This file includes supplemental Tables (S1–S8)—Table S1. Comparison of cell-proportions and lung function variables across the Stage-1 (n = 91) and Stage-2 (n = 279) samples from the IOW F1 Sample. Table S2. Parameter estimates from logistic regression models performed in the Stage-2 sample (ns2 = 279), regressing current asthma status on DNA methylation M-values for all CpGs selected from the Stage-1 analysis. Table S3. Parameter estimates, standard errors, and p-values to compare the IOW F1 results to the ALSPAC replication results for CpGs that yielded an association within a 5% FDR in the Stage-2 analysis. Table S4. Comparing adjustment covariates between the IOW F1 sample and the ALSPAC sample; the within cohort comparisons are testing for differences in these variables between those with and without asthma. Table S5. Results from linear asthma EWAS in IOW F1 (n = 370), in which methylation beta values were regressed on asthma status, unadjusted for possible confounders. Table S6. Results from linear asthma EWAS in IOW F1 (n = 370), in which methylation beta values were regressed on asthmat status, adjusted for sex, CD4T cells, CD8T cells, Monocytes, Natural Killers, Eosinophils, and other Granulocytes. Table S7. CpGs that yielded unadjusted association (p < 0.001) with current asthma in IOW F1 (unadjusted models) that were also identified as having unadjusted associations with current asthma and wheeze at age 7.5 and 16.5 years old in the previously published ALSPAC EWAS. Table S8. Associations between asthma and DNA methylation within the IOW cohort (unadjusted models) at the 14 CpGs that were identified as being asthma associated in a meta analysis of European children.