Crystal structure of human cellular retinol binding protein 1 in complex with methyl({3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}methyl)[(1-methylpyrazol-4-yl)methyl]amine

Crystal structure of human cellular retinol binding protein 1 in complex with methyl({3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}methyl)[(1-methylpyrazol-4-yl)methyl]amine Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-[(1-methyl-1H-pyrazol-4-yl)methyl]methanamine, Retinol-binding protein 1 Authors: Plau, J, Golczak, M. Deposit date: 2023-03-07 Release date: 2023-10-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. Acs Chem.Biol., 18, 2023人细胞视黄醇结合蛋白1（cellular retinol binding protein 1, CRBP1）与甲基({3-[1-(4-甲基苯基)环戊基]-1,2,4-噁二唑-5-基}甲基)[(1-甲基吡唑-4-基)甲基]胺复合物的晶体结构。描述项：2-[双(2-羟乙基)氨基]-2-羟甲基丙烷-1,3-二醇、N-甲基-1-{3-[1-(4-甲基苯基)环戊基]-1,2,4-噁二唑-5-基}-N-[(1-甲基-1H-吡唑-4-基)甲基]甲胺、视黄醇结合蛋白1。作者：Plau J、Golczak M。提交日期：2023年3月7日。发布日期：2023年10月11日。最后修改日期：2023年11月1日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.47埃。引用文献：《CRBP1非视黄醇类抑制剂的发现：配体结合机制的结构与动态洞察》，发表于《ACS化学·生物学》（Acs Chem.Biol.），第18卷，2023年。