Gut microbiota associated metabolic alterations disclosed the gut-brain associations in Alzheimer disease mice. Gut microbiota

Alzheimer's disease (AD) is a progressive neurodegenerative disease related to various factors. For its crucial roles in immune regulation and neuro-related metabolite secretion, gut microbiome (GM) has been explored for the investigation of AD pathogenesis. However, there are various uncontrollable environmental factors (such as age, diet habits, drug administration, etc.) that affect the accurate GM investigations in AD patients, and the correlation landscape between GM and metabolomes from the periphery to the brain remains unraveled.