Interuption of Klf5 acetylaiton at K358 affects tumor microenvironment in Pten deficient mouse prostates
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1094424
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资源简介：
PTEN deficiency induces KLF5 acetylation; and the interruption of KLF5 acetylation orchestrates intricate interactions between cancer cells and CAFs that enhance FGFR1 signaling and promote tumor growth. Deacetylated KLF5 promotes tumor cells to secrete TNF, which stimulates inflammatory CAFs to release FGF9. Single-cell transcriptomic analysis reveals an enhanced FGF signaling from fibroblasts to cancer cells after the interruption of Klf5 acetylation.
创建时间：
2024-03-30
