Solid state NMR spectra of amyloid-beta fibrils derived from mouse brain tissue

One- and two-dimensional solid state NMR spectra of 40-residue amyloid-beta fibrils that were seeded with amyloid-enriched extracts from brain tissue of Tg2576 mice, which had been treated with two different synthetic fibril polymorphs (2F and 3F polymorphs) or with brain material from aged Tg2576 mice. The contents of each folder are described in the README.txt file. These solid state NMR data appear in a publication by R. Gomez-Gutierrez et al., entitled "Two Structurally Defined Abeta Polymorphs Promote Different Pathological Changes in Susceptible Mice".

本数据集包含了由40个氨基酸残基组成的淀粉样-β纤维的单一和二维固态核磁共振光谱，这些纤维是通过在Tg2576小鼠脑组织中富含淀粉样物质的提取液中培养而得，该小鼠曾接受过两种不同的合成纤维多形体（2F和3F多形体）或老年Tg2576小鼠的脑组织处理。每个文件夹的内容在README.txt文件中均有详细描述。这些固态核磁共振数据由R. Gomez-Gutierrez等人发表在题为《两种结构明确的Abeta多形体在易感小鼠中促进不同的病理变化》的论文中。