Background: We had shown that cardiomyocytes (CMs) were more efficiently differentiated from human induced pluripotent stem cells (hiPSCs) when the hiPSCs were reprogrammed from cardiac fibroblasts ra

NIAID Data Ecosystem50

Hand2 selectively reorganizes chromatin accessibility to induce pacemaker-like transcriptional reprogramming (RNA-seq). Hand2 selectively reorganizes chromatin accessibility to induce pacemaker-like transcriptional reprogramming (RNA-seq)

心脏起搏细胞重编程

染色质可及性调控

Gata4, Mef2c, Hand2, and Tbx5 (GHMT) can reprogram transduced fibroblasts into induced pacemaker-like myocytes (iPMs), but the underlying mechanisms remain obscure. Here we explored the role of Hand2

NIAID Data Ecosystem30

Whole transcriptional analysis of induced cardiomyocytes from MICFs. Whole transcriptional analysis of induced cardiomyocytes from MICFs

心脏起搏细胞重编程

RNA-seq转录组学

We report that Sall4 and Myocd empower direct cardiac reprogramming from adult cardiac fibroblasts after myocardial infarction (MICFs). To examine the gene expression of induced cardiomyocytes (iCMs)

NIAID Data Ecosystem60

Transcriptome analysis of Tbx18-induced pacemaker cells (TBX18-iPMs) in comparison to ventricular cardiomyocytes

心脏起搏细胞重编程

比较转录组分析

To understand the transcriptional landscape of Tbx18-induced cardiac pacemaker cells. The control cells were ventricular myocytes expressing GFP. Overall design: Neonatal rat ventricular myocytes (NRV

NIAID Data Ecosystem30

Global gene expression in adult cardiac fibroblasts transduced with cardiac transcription factor

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