Synthesis and Anti-inflammatory Evaluation of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-<i>a</i>]Pyrimidine, Imidazo[1,2-<i>b</i>]Pyrazole and Pyrazolo[5,1-<i>b</i>]Quinazoline Derivatives Containing Indane Moiety

A new series of pyrazole, pyrimidine, pyrazolo[1,5-<i>a</i>]pyrimidine, imidazo[1,2-<i>b</i>]pyrazole and pyrazolo[5,1-<i>b</i>]quinazoline derivatives containing indane moiety are prepared by using <i>N</i>-(2,3-dihydro-1<i>H</i>-inden-5-yl)carbonohydrazonoyl dicyanide (<b>2</b>) as starting material to synthetic different heterocyclic compounds (<b>3</b>–<b>11</b>) by the reaction with different bifuncation reagents. Moreover, 4-((2,3-dihydro-1<i>H</i>-inden-5-yl)diazenyl)-1<i>H-</i>pyrazole-3,5-diamine (<b>3</b>) was taken as a precursor to prepare different pyrazolo[1,5-<i>a</i>]pyrimidine derivatives (<b>12</b>–<b>20</b>). The structures of newly synthesized compounds were confirmed on the basis of their IR, 1H NMR, 13C NMR, and mass spectral data. All compounds were evaluated as anti-inflammatory activity by using carrageenan-induced rat paw edema test. In comparison to the standard drug diclofenac sodium, compounds <b>3</b>, <b>7</b>, <b>9</b>, and <b>11</b> exhibited potent activity than standard drug. The compounds <b>2</b> and <b>8</b> showed the most significant anti- anti-inflammatory with 64.83 and 63.95% inhibition of edema.