Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Descriptor: 4-amino-2-methyl-N-(1H-pyrazol-3-yl)quinazoline-8-carboxamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Knighton, D.R, Greasley, S.E, Rodgers, C.M.-L. Deposit date: 2010-11-30 Release date: 2011-02-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 21, 2011

以分子内氢键骨架（intra-molecular hydrogen bonding scaffold，iMHBS）为母核的喹唑啉类PI3K/mTOR双重抑制剂。化合物标识：4-氨基-2-甲基-N-(1H-吡唑-3-基)喹唑啉-8-甲酰胺；作用靶点：磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ亚型（Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform）。作者：Knighton, D.R.、Greasley, S.E.、Rodgers, C.M.-L.。存入日期：2010-11-30。发布日期：2011-02-09。最后修改日期：2024-02-21。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.6 Å。引用文献：以分子内氢键骨架（iMHBS）为母核的喹唑啉类PI3K/mTOR双重抑制剂。《Bioorg.Med.Chem.Lett.》，第21卷，2011年。