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Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

NIAID Data Ecosystem2026-03-13 收录

PROTAC靶向降解

细胞基因调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE194348 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2022-07-20

表观遗传学分析

细胞基因调控

H3K36me3 ChIP-seq on CD4-positive, alpha-beta T cell male adult (20 years) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research

NIAID Data Ecosystem80

Mint-ChIP-seq from activated B cell (ENCSR685KZA)

表观遗传学

细胞基因调控

H3K27ac ChIP-seq on B cell male adult (22 years) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Po

NIAID Data Ecosystem30

RNA-seq data from nsd2 wt and ko germinal center B cells. RNA-seq data from nsd2 wt and ko germinal center B cells

细胞基因调控

RNA-seq差异表达分析

The goal of this study was to invetigate the mechanisms by which nsd2 regulate germinal center reaction by comparing RNA-seq data between nsd2 wt and ko germinal center B cells Overall design: 2×10e6

NIAID Data Ecosystem20

Table3_A genome–wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs.XLSX

非编码RNA功能

细胞基因调控

The genome is pervasively transcribed to produce a vast array of non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides and are best known for their ability to re

NIAID Data Ecosystem30

Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl‑2 Derived from Nonselective Target Binding Ligands

PROTAC靶向降解

Bcl-2家族抗凋亡蛋白

Proteolysis targeting chimera (PROTAC) recruits an E3 ligase to a target protein to induce its ubiquitination and subsequent degradation. We reported success in the development of two PROTACs (C3 and

NIAID Data Ecosystem20

Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

资源简介：

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