Effects of maternal Type 1 Diabetes on neonatal microbiomes

This is the Supporting Dataset for the manuscript 'Effects of maternal Type 1 Diabetes on neonatal microbiomes' by Gajecka et al. in the Diabetologia.

Mendeley Supplementary Figure 1. The predicted differently represented pathways in the rectum swabs of women with type 1 diabetes (PICRUSt analysis). The 10 pathways were recognised including 2 pathways from the carbohydrate biosynthesis class. In women with type 1 diabetes decreased folate biosynthesis (N10-formyl-tetrahydrofolate biosynthesis) was noticed. The SCFA production in the rectum swabs of women with type 1 diabetes was found lowered (acetyl-CoA fermentation to butanoate II, purine nucleobases degradation I (anaerobic)). The Generation of Precursor Metabolites and Energy (from superpathway of glycolysis and Entner-Doudoroff) was also decreased.

Mendeley Supplementary Table 1. Differentially represented metagenomic pathways, predicted using a PICRUSt bioinformatics software package. Sheet1 presents 165 predicted pathways, significantly differentiated by comparing three vaginal sampling sites of women with T1D with samples of control women. Sheet2 contains 10 pathways predicted as differentially represented in the rectum swabs. Sheet 3 shows the analysis of combined neonatal ear-skin swabs and stool samples. Sheet 4 presents pathways predicted to differ depending on maternal disease status regarding neonatal stool samples. Sheet5 shows pathways of ear-skin swabs differently represented in neonates born to T1D and control mothers. The influence of mode of delivery on pathways prediction is presented in Sheet6.

Mendeley Supplementary Table 2. The intake of probiotics during pregnancy in the form of probiotics and/or synbiotics (the qualitative data). The assessment did not take into account the actual amounts of taken probiotic and/or synbiotic supplements, and probiotics and prebiotics from various types of probiotic food products consumed by the surveyed women.