MPST
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=735977
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This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
该基因编码的蛋白质催化将硫离子从3-巯基丙酮酸转移到氰化物或其他硫醇化合物。该蛋白可能参与半胱氨酸的降解和氰化物的解毒作用。在文献中，关于此蛋白（巯基丙酮酸硫转移酶，MPST）和硫代硫酸盐硫转移酶（罗丹宁，TST，GeneID:7263）之间存在混淆，后者是一种线粒体蛋白，而MPST似乎定位于细胞质中。MPST活性不足已被归因于一种罕见的遗传性疾病——巯基乳酸-半胱氨酸二硫化物尿症（MCDU）。对于该基因，已鉴定出编码相同或不同异构体的选择性剪接转录变体。[由RefSeq提供，2008年7月]
提供机构：
Rat Genome Database
