Macronutrients modulate survival to infection and immunity in Drosophila

Immunity and nutrition are two essential modulators of individual fitness. However, while the implications of immune function and nutrition on an individual’s lifespan and reproduction are well established, the interplay between feeding behaviour, infection, and immune function, remains poorly understood. Asking how ecological and physiological factors affect immune responses and resistance to infections is a central theme of eco-immunology.
In this study, we used the fruit fly, Drosophila melanogaster, to investigate how infection through septic injury modulates nutritional intake, and how macronutrient balance affects survival to infection by the pathogenic Gram-positive bacterium Micrococcus luteus.
Our results show that infected flies maintain carbohydrate intake, but reduce protein intake, thereby shifting from a protein-to-carbohydrate (P:C) ratio of ~1:4 to ~1:10 relative to non-infected and sham-infected flies. Strikingly, the proportion of flies dying after M. luteus inf...