Dihydroartemisinin Beneficially Regulates Splenic Immune Cell Heterogeneity through the SOD3-JNK-AP-1 Axis

The immunomodulatory potential of dihydroartemisinin (DHA) has recently been highlighted; however, the potential mechanism remains to be clarified. In this study, we found that DHA induced both spleen enlargement and rearrangement of splenic immune cell subsets in mice. To elucidate the immunomodulatory mechanisms of DHA, single-cell RNA sequencing was explored in combination with cellular and biochemical approaches.