Supplemental Data to: Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Objective: To determine whether following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional data from the German DZNE-Longitudinal Cognitive Impairment and Dementia Study. Method: The sample (n = 512, mean age 69.5 ± 5.9 years) included 169 cognitively normal participants and individuals at higher AD risk (53 with relatives with AD, 209 with subjective cognitive decline, and 81 with mild cognitive impairment). We defined MeDi adherence according to the food frequency questionnaire. Brain volume outcomes were generated via voxel-based morphometry on T1-MRI, and cognitive performance was assessed with an extensive neuropsychological battery. AD-related biomarkers (β-amyloid42/40 [Aβ42/40] ratio, phosphorylated tau 181 [pTau181]) in CSF were assessed in n = 226 individuals. We analyzed the associations between MeDi and outcomes with linear regression models controlling for several covariates. I...研究目的：为明确类地中海饮食（Mediterranean-like diet, MeDi）与认知功能及阿尔茨海默病（Alzheimer disease, AD）体内生物标志物的关联，我们对德国DZNE纵向认知障碍与痴呆研究的横断面数据进行了分析。 研究方法：本次研究样本量为512例，平均年龄69.5±5.9岁，纳入169名认知正常参与者，以及阿尔茨海默病高风险人群：53名有阿尔茨海默病家族史者、209名主观认知下降者与81名轻度认知障碍者。我们通过食物频率问卷（food frequency questionnaire）评估受试者对类地中海饮食的依从性。采用基于体素的形态测量法（voxel-based morphometry）对T1加权磁共振成像（T1-MRI）数据进行处理以获取脑体积相关指标，并通过一套全面的神经心理学评估量表（neuropsychological battery）对认知表现进行测评。针对226名受试者的脑脊液（cerebrospinal fluid, CSF），我们检测了其阿尔茨海默病相关生物标志物——β-淀粉样蛋白42/40（β-amyloid42/40, Aβ42/40）比值与磷酸化tau蛋白181（phosphorylated tau 181, pTau181）水平。我们采用线性回归模型（linear regression models）分析类地中海饮食依从性与各项研究结局的关联，并对多项协变量（covariates）进行了控制。I...