Analgesic effect of the mint terpenoid L-Carvone in sheep

Objective: To determine whether L‑carvone increases the voltage threshold response to a noxious electrical stimulus in sheep.
Study Design: Prospective, blinded, randomized, crossover experimental study.
Animals: A group of 6 adult sheep.
Methods: Sheep were instrumented with cranial dorsothoracic subcutaneous copper electrodes. A stimulator delivered a 10ms square wave at 50 pps starting at 0.1V with a 0.2V/s ramp. The stimulus stopped once two observers who were blinded to treatment noted a behavioral pain response or when a 15V cut-off was reached. Next, 0.15 mL kg−1 of either a 50% L‑carvone solution or a saline-vehicle control was administered intramuscularly, and electrical threshold responses were measured every 5-to-15 min over a 6-hour period using methods identical to the baseline. One week following the first treatment (L‑carvone or control), sheep were studied using identical methods with the second treatment (control or L‑carvone). Drug and time effects were evaluated using..., , , # Analgesic effect of the mint terpenoid L-carvone in sheep

**Description of the data and file structure**

* Voltage Threshold dryad.xlsx: This file contains the stimulus threshold (in volts) to produce a behavioral response to the noxious stimulus. Responses in animals treated with L-carvone are on the L-carvone data page. Responses for control animals are on the saline data page.

- respiratory rate dryad.xlsx: This file contains the respiratory rate (breaths/min) counted before voltage threshold testing at each time point. Responses in animals treated with L-carvone are on the L-carvone data page. Responses for control animals are on the saline data page.

* eating periods dryad.xlsx: This file contains the number of periods (out of 28 measurement periods) in which animals were observed eating during treatment with L-carvone and treatment with the saline control.

In the data sets, the time indicates the number of minutes following IM (intra-muscular) administration of either L...