Supplemental materials for PAC1 deficiency protects immobilization-induced muscle atrophy in obese male mice by suppressing FoxO-atrogene axis.docx

Supplemental materials, including gene set enrichment analysis data and others. Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function and its role in the skeletal muscles remains under-investigated. Here, we established skeletal muscle-specific 20S proteasome assembly chaperone-1 (PAC1) knockout (mPAC1KO) mice.