Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand

Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand Descriptor: (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2 Authors: Filippakopoulos, P, Myrianthopoulos, V, Kritsanida, M, Magiatis, P, Skaltsounis, A.L, Soundararajan, M, Krojer, T, Gileadi, O, Hapka, E, Fedorov, O, Berridge, G, Wang, J, Shrestha, L, Vollmar, M, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Mikros, E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2009-11-30 Release date: 2010-01-05 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand To be Published

双特异性酪氨酸磷酸化调节激酶2（DYRK2）与靛玉红（indirubin）配体结合的晶体结构
配体描述：(2Z,3E)-7'-溴-3-(羟基亚氨基)-2'-氧代-1,1',2',3-四氢-2,3'-双吲哚-5-羧酸、氯离子
作者：Filippakopoulos P、Myrianthopoulos V、Kritsanida M、Magiatis P、Skaltsounis A.L、Soundararajan M、Krojer T、Gileadi O、Hapka E、Fedorov O、Berridge G、Wang J、Shrestha L、Vollmar M、von Delft F、Arrowsmith C.H、Edwards A、Weigelt J、Bountra C、Mikros E、Knapp S、结构基因组学联合体（Structural Genomics Consortium, SGC）
提交日期：2009年11月30日
发布日期：2010年1月5日
最后修改日期：2024年10月9日
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.28 Å
引用：双特异性酪氨酸磷酸化调节激酶2（DYRK2）与靛玉红（indirubin）配体结合的晶体结构，待发表