Efficacy of reduction (in %) at year 90 in males and females with OA treated with UC-II and fisetin (<i>D</i>).

UC-II is administered daily for 6 months, followed by a 6-month break, in repeated cycle. Fisetin is taken daily for 7 days, followed by a 7-day break, in a repeating cycle. Treatment begins at various times (Treatment Initiation) and ends at year 90 (Endtime).